沙冲 博士 讲师 硕士生导师
教育背景
2009.09至2015.06，江南大学 生物工程学院，发酵工程，获博士学位；
2005.09至2009.06，江南大学 生物工程学院，生物工程，获学士学位。
工作经历
2026年9月-至今 江苏大学 生物科学与技术学院
2015年9月-2026年8月 江苏大学 环境与安全工程学院生物质能源研究院
2019年7月-至今 山东福田药业有限公司 博士后
研究领域
研究新型工业用酶的克隆与高效表达技术；
利用合成生物学技术实现高附加值产物的全细胞合成及转化；
研究光/电驱动的生物合成及电子传递机制；
开发并研究新质蛋白及其营养与功能。
科研项目
壳寡糖酶法合成的技术开发，2021年12月-至今，主持，在研；
江苏省碳达峰碳中和科技创新专项资金，2022年1月-2024年12月，项目骨干，已结题；
江苏省自然科学基金青年基金项目，主持，已结题。
主要研究论文
1. Zi-Jie Lu, Jia-Qi Zang, Xing-Ming Zhao, Nan Ding, Li-Xin Dai, Tian-Yu Zhu, Jun-Ying Liu, Chong Sha, Yang-Chun Yong*. A synthetic protein plug for assembly of bio-nano-hybrids with direct electron transfer powered photobiocatalysis. Chemical Communications, 2026, 62(51), 12926-12930.
2. Zi-Jie Lu, Chong Sha, Tian-Yu Zhu, Jun-Ying Liu, Yang-Chun Yong*. Boosting photoactivation of microorganisms by covalent binding of nanoparticles to membrane proteins. Chemical Engineering Journal, 2025, 525, 170654.
3. Tian-Yu Zhu, Yi-Cheng Zhao, Chong Sha*, Said Nawab, Jun-Ying Liu, Yang-Chun Yong*. Enhanced hydrogen production by robust covalent biohybrid based on cell membrane specific click chemistry. Bioresource Technology, 2025, 427, 132410.
4. Ze-Peng Wen, Chong Sha*, Said Nawab, Zi-Jie Lu, Yang-Chun Yong*. One-step transformation of CO2 to methane by Escherichia coli with a synthetic biomethanation module. Biochemical and Biophysical Research Communications, 2025, 746, 151284.
5. Yi-Cheng Zhao#, Chong Sha#, Xing-Ming Zhao, Jia-Xin Du, Long Zou, Yang-Chun Yong*. Unnatural Direct Interspecies Electron Transfer Enabled by Living Cell-Cell Click Chemistry. Angewandte Chemie International Edition, 2024, e202402318.
6. Beenish Sadaqat, Mudasir A. Dar, Chong Sha, Abdelfatah Abomohra, Weilan Shao*, Yang-Chun Yong*. Thermophilic β-mannanases from bacteria: production, resources, structural features and bioengineering strategies. World Journal of Microbiology and Biotechnology, 2024, 40(4), 130.
7. Jamile Mohammadi Moradian, Fu-Qiao Yang, Nuo Xu, Jia-Yi Wang, Jing-Xian Wang, Chong Sha*, Amjad Ali, Yang-Chun Yong. Enhancement of bioelectricity and hydrogen production from xylose by a nanofiber polyaniline modified anode with yeast microbial fuel cell. Fuel，2022, 326, 125056.
8. Chong Sha, Qiang Wang, Hongcheng Wang, Yilan Duan, Chongmao Xu, Lian Wu, Kesen Ma, Weilan Shao*, and Yu Jiang*. Characterization of Thermotoga neapolitana Alcohol Dehydrogenases in the Ethanol Fermentation Pathway. Biology-Basel, 2022, 11, 1318.
9. Chong Sha, Beenish Sadaqat, HongchengWang, Xingxing Guo, Weilan Shao⁎. Efficient xylan-to-sugar biotransformation using an engineered xylanase in hyperthermic environment. International Journal of Biological Macromolecules, 2020,157, 17-23.
10. Beenish Sadaqat#, Chong Sha#, Parveen Fatemeh Rupani, Hongcheng Wang, Wanbing Zuo and Weilan Shao*. Man/Cel5B, a Bifunctional Enzyme Having the Highest Mannanase Activity in the Hyperthermic Environment. Frontiers in Bioengineering and Biotechnology, 2021, 9, 637649.
11. Qiang Wang#, Chong Sha#, Hongcheng Wang, Kesen Ma, Juergen Wiegle, Abd El‑Fatah Abomohra* & Weilan Shao*. A novel bifunctional aldehyde/alcohol dehydrogenase catalyzing reduction of acetyl-CoA to ethanol at temperatures up to 95 degrees C. Scientific Reports, 2021, 11, 1050.
12. 邵蔚蓝，郭星星，沙冲*。大肠杆菌热休克或冷休克启动子调控的基因表达载体，微生物学通报，2017，44（6）：1464-1470.
13. Chong Sha, Xiao-Wei Yu, Yan Xu, et al. Enhancement of lipase r27RCL production in Pichia pastoris by regulating gene dosage and co-expression with chaperone Protein Disulfide Isomerase. Enzyme and Microbial Technology, 2013, 53: 438-443.
14. Chong Sha, Xiao-Wei Yu, Yan Xu, et al. Efficient secretion of lipase r27RCL in Pichia pastoris by enhancing the disulfide bond formation pathway in the Endoplasmic Reticulum. Journal of Industrial Microbiology and Biotechnology, 2013, 40: 1241-1249.
15. Chong Sha, Xiao-Wei Yu, Yan Xu, et al. Impact of gene dosage on the Production of lipase from Rhizopus chinensis CCTCC M201021 in Pichia pastoris. Applied Biochemistry and Biotechnology, 2013, 169: 1160-1172.
16. Xiao-Wei Yu, Chong Sha, Yong-Liang Guo, Rong Xiao, Yan Xu, High-level expression and characterization of a chimeric lipase from Rhizopus oryzae for biodiesel production. Biotechnology for Biofuels, 2013, 6: 29.
联系地址及方式
江苏省镇江市学府路301号，江苏大学生物质能源研究院，邮编212013.
电子邮箱：shachong@ujs.edu.cn
